Multimonth controlled small molecule release from biodegradable thin films
نویسندگان
چکیده
منابع مشابه
Multimonth controlled small molecule release from biodegradable thin films.
Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity to vital organs typically caused by systemic administration and decreasing the ...
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Multidrug regimens can sometimes treat recalcitrant diseases when single-drug therapies fail. Recapitulating complex multidrug administration from controlled release films for localized delivery remains challenging because their release kinetics are frequently intertwined, and an initial burst release of each drug is usually uncontrollable. Kinetic control over protein release is demonstrated b...
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The design of biocompatible polymers and materials with multiple functional groups is a true challenge for synthetic chemists. These materials have to fulfil numerous criteria: they should possess multiple functions for attachment of biomolecules, control of surface properties, etc. while at the same time meeting strict performance requirements for biocompatibility, biodegradation, adhesion, fl...
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Incorporation of orthogonal functional groups into biodegradable polymers permits the fabrication of multi-layered thin films with improved adhesion and tunable degradation profiles. The bi-layer structure also allows for accurate control over small molecule release.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1323829111